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Tyk2 is dispensable for induction of myeloproliferative disease by mutant FLT3NAKAJIMA, Hideaki; SHIBATA, Fumi; KUMAGAI, Hidetoshi et al.International journal of hematology. 2006, Vol 84, Num 1, pp 54-59, issn 0925-5710, 6 p.Article

Diagnostic approach to the hyper-IgE syndromes: Immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitisSCHIMKE, Lena F; SAWALLE-BELOHRADSKY, Julie; REICHENBACH, Janine et al.Journal of allergy and clinical immunology. 2010, Vol 126, Num 3, pp 611-617, issn 0091-6749, 7 p.Article

Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitorsPISSOT-SOLDERMANN, Carole; GERSPACHER, Marc; TAVARES, Gisele A et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 8, pp 2609-2613, issn 0960-894X, 5 p.Article

A role for Janus kinases in crosstalk between ErbB3 and the interferon-alpha signaling complex in myeloma cellsWALTERS, Denise K; JELINEK, Diane F.Oncogene (Basingstoke). 2004, Vol 23, Num 6, pp 1197-1205, issn 0950-9232, 9 p.Article

Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-γ production and the induction of Th1 cell differentiationTOKUMASA, Naoki; SUTO, Akira; KAGAMI, Shin-Ichiro et al.Blood. 2007, Vol 110, Num 2, pp 553-560, issn 0006-4971, 8 p.Article

IFN-γ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 productionCONZELMANN, Michael; WAGNER, Andreas H; HECKER, Markus et al.Biochemical pharmacology. 2010, Vol 80, Num 12, pp 2074-2086, issn 0006-2952, 13 p.Conference Paper

2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitorsGERSPACHER, Marc; FURET, Pascal; CHENE, Patrick et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 5, pp 1724-1727, issn 0960-894X, 4 p.Article

Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heartPAN, J; FUKUDA, K; KODAMA, H et al.Circulation research. 1997, Vol 81, Num 4, pp 611-617, issn 0009-7330Article

A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosisMERO, Inger-Lise; LORENTZEN, Aslaug R; KOCKUM, Ingrid et al.European journal of human genetics. 2010, Vol 18, Num 4, pp 502-504, issn 1018-4813, 3 p.Article

Evidence for Genetic Association and Interaction Between the TYK2 and IRF5 Genes in Systemic Lupus ErythematosusHELLQUIST, Anna; JARVINEN, Tiina M; SAARIALHO-KERE, Ulpu et al.Journal of rheumatology. 2009, Vol 36, Num 8, pp 1631-1638, issn 0315-162X, 8 p.Article

Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factorBAN, Maria; GORIS, An; DUBOIS, Bénédicte et al.European journal of human genetics. 2009, Vol 17, Num 10, pp 1309-1313, issn 1018-4813, 5 p.Article

Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growthKATO, Kouji; KAMEZAKI, Kenjirou; MIYAMOTO, Toshihiro et al.British journal of haematology. 2003, Vol 123, Num 3, pp 528-535, issn 0007-1048, 8 p.Article

A protein tyrosine kinase in the interferon α/β signaling pathwayVELAZQUEZ, L; FELLOUS, M; STARK, G. R et al.Cell (Cambridge). 1992, Vol 70, Num 2, pp 313-322, issn 0092-8674Article

Predicted tyk2 protein contains two tandem protein kinase domainsBERNARDS, A.Oncogene : (Basingstoke). 1991, Vol 6, Num 7, pp 1185-1187Article

Reduced Tyk2/SHP-1 interaction and lack of SHP-1 mutation in a kindred of familial hemophagocytic lymphohistiocytosisTABRIZI, M; YANG, W; JIAO, H et al.Leukemia. 1998, Vol 12, Num 2, pp 200-206, issn 0887-6924Conference Paper

Constitutive STAT1 tyrosine phosphorylation in U937 monocytes overexpressing the TYK2 protein tyrosine kinase does not induce gene transcriptionEILERS, A; KANDA, K; KLOSE, B et al.Cell growth and differentiation. 1996, Vol 7, Num 6, pp 833-840, issn 1044-9523Article

Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosusJÄRVINEN, Tiina M; HELLQUIST, Anna; KERE, Juha et al.Experimental dermatology. 2010, Vol 19, Num 2, pp 123-131, issn 0906-6705, 9 p.Article

Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3MALERICH, Jeremiah P; LAM, Jennifer S; HART, Barry et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 24, pp 7454-7457, issn 0960-894X, 4 p.Article

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibilityCOUTURIER, Nicolas; BUCCIARELLI, Florence; GOERTSCHES, Robert H et al.Brain. 2011, Vol 134, pp 693-703, issn 0006-8950, 11 p., 3Article

Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient miceSHIMODA, Kazuya; TSUTSUI, Hiroko; ASANO, Yoshinobu et al.Blood. 2002, Vol 99, Num 6, pp 2094-2099, issn 0006-4971Article

The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-αSUIYANG LI; LABRECQUE, S; GAUZZI, M. C et al.Oncogene (Basingstoke). 1999, Vol 18, Num 42, pp 5727-5737, issn 0950-9232Article

Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE familiesGRAHAM, D. S. C; AKIL, M; VYSE, T. J et al.Rheumatology (Oxford. Print). 2007, Vol 46, Num 6, pp 927-930, issn 1462-0324, 4 p.Article